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Endocrine Abstracts

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ea0003oc44 | Neuroendocrinology | BES2002

MSH precursor peptides in rat cerebrospinal fluid: Evidence that pro-opiomelanocortin (POMC) processing is regulated with respect to energy balance

Pritchard L , Oliver R , McLoughlin J , Birtles S , Turnbull A , White A

Pro-opiomelanocortin (POMC) derived peptides coordinate energy balance via central melanocortin receptors. In order to monitor central POMC expression and processing in-vivo, we have quantified the POMC derived peptides ACTH, alpha-MSH and the high molecular weight precursors POMC/proACTH in rat cerebrospinal fluid (csf). POMC/proACTH levels were significantly lower in csf samples from fasted versus fed rats (65.2 ± 4.5 pmol/l versus 112 ± 10.1 pmol/l; p = 0.00...
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Published by BioScientifica

Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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